| NCAAF | 11/16 18:30 | 1 | Otterbein Cardinals v Wilmington Quakers | L | 27-28 | |
| NCAAF | 11/09 18:30 | 1 | Marietta Pioneers v Otterbein Cardinals | L | 21-10 | |
| NCAAF | 11/02 17:30 | 1 | Capital Crusaders v Otterbein Cardinals | W | 18-33 | |
| NCAAF | 10/26 17:30 | 1 | Otterbein Cardinals v Muskingum Muskies | W | 18-10 | |
| NCAAF | 10/19 23:00 | 1 | Heidelberg Student Princes v Otterbein Cardinals | L | 52-35 | |
| NCAAF | 10/05 17:30 | 1 | Mount Union v Otterbein Cardinals | L | 58-0 | |
| NCAAF | 09/28 22:00 | 1 | Ohio Northern Polar Bears v Otterbein Cardinals | L | 45-35 | |
| NCAAF | 09/21 18:00 | 1 | Otterbein Cardinals v John Carroll Blue Streaks | L | 7-14 | |
| NCAAF | 09/14 18:00 | 1 | Otterbein Cardinals v Baldwin Wallace Yellow Jackets | L | 28-45 | |
| NCAAF | 09/07 18:00 | 1 | Ohio Wesleyan Battling Bishops v Otterbein Cardinals | L | 22-10 | |
| NCAAF | 11/10 18:30 | 1 | Wilmington Quakers v Otterbein Cardinals | W | 24-34 | |
| NCAAF | 11/03 17:30 | 1 | Otterbein Cardinals v Marietta Pioneers | L | 21-43 | |
| NCAAF | 10/27 17:30 | 1 | Otterbein Cardinals v Capital Crusaders | L | 19-23 | |
| NCAAF | 10/20 18:00 | 1 | Muskingum Muskies v Otterbein Cardinals | L | 21-14 | |
| NCAAF | 10/13 23:00 | 1 | Otterbein Cardinals v Heidelberg Student Princes | L | 7-21 | |
| NCAAF | 09/29 17:30 | 1 | Otterbein Cardinals v Mount Union | L | 14-56 | |
| NCAAF | 09/22 18:00 | 1 | Otterbein Cardinals v Ohio Northern Polar Bears | L | 7-13 | |
| NCAAF | 09/15 17:30 | 1 | John Carroll Blue Streaks v Otterbein Cardinals | L | 45-0 | |
| NCAAF | 09/08 22:00 | 1 | Baldwin Wallace Yellow Jackets v Otterbein Cardinals | L | 33-3 | |
| NCAAF | 09/01 17:30 | 1 | Otterbein Cardinals v Ohio Wesleyan Battling Bishops | W | 10-7 |