| NCAAF | 11/18 17:00 | 7 | Alma College Scots v Depauw Tigers | L | 32-17 | |
| NCAAF | 11/11 18:07 | 1 | Wabash Little Giants v Depauw Tigers | W | 30-33 | |
| NCAAF | 10/28 16:00 | 1 | Depauw Tigers v Kenyon Lords | W | 58-7 | |
| NCAAF | 10/21 18:00 | 1 | Wittenberg Tigers v Depauw Tigers | W | 35-41 | |
| NCAAF | 10/14 18:00 | 1 | Wooster Scots v Depauw Tigers | W | 7-53 | |
| NCAAF | 10/07 17:00 | 1 | Depauw Tigers v Denison Big Red | W | 17-6 | |
| NCAAF | 09/30 17:00 | 1 | Oberlin Yeomen v Depauw Tigers | W | 7-66 | |
| NCAAF | 09/23 17:00 | 1 | Depauw Tigers v Ohio Wesleyan Battling Bishops | W | 28-7 | |
| NCAAF | 09/16 17:00 | 1 | Depauw Tigers v Hiram Terriers | W | 49-0 | |
| NCAAF | 09/09 17:00 | 1 | Depauw Tigers v Anderson Ravens | W | 68-19 | |
| NCAAF | 09/02 23:00 | 1 | Rose Hulman Engineers v Depauw Tigers | W | 21-33 | |
| NCAAF | 11/19 17:00 | 7 | Carnegie Mellon Tartans v Depauw Tigers | L | 45-14 | |
| NCAAF | 11/12 18:07 | 1 | Depauw Tigers v Wabash Little Giants | W | 49-14 | |
| NCAAF | 11/05 17:00 | 1 | Depauw Tigers v Oberlin Yeomen | W | 72-0 | |
| NCAAF | 10/29 17:00 | 1 | Kenyon Lords v Depauw Tigers | W | 35-58 | |
| NCAAF | 10/22 17:00 | 1 | Ohio Wesleyan Battling Bishops v Depauw Tigers | W | 21-22 | |
| NCAAF | 10/08 17:00 | 1 | Depauw Tigers v Wittenberg Tigers | L | 7-30 | |
| NCAAF | 10/01 23:00 | 1 | Denison Big Red v Depauw Tigers | W | 13-17 | |
| NCAAF | 09/24 17:00 | 1 | Depauw Tigers v Wooster Scots | W | 59-0 | |
| NCAAF | 09/17 16:00 | 1 | Hiram Terriers v Depauw Tigers | W | 0-44 | |
| NCAAF | 09/10 22:00 | 1 | Anderson Ravens v Depauw Tigers | W | 0-55 | |
| NCAAF | 09/03 17:00 | 1 | Depauw Tigers v Rose Hulman Engineers | W | 17-14 | |
| NCAAF | 11/27 18:00 | 8 | UW-Whitewater v Depauw Tigers | L | 45-0 | |
| NCAAF | 11/20 17:00 | 7 | Depauw Tigers v Rose Hulman Engineers | W | 26-21 | |
| NCAAF | 11/13 18:07 | 1 | Wabash Little Giants v Depauw Tigers | L | 42-35 | |
| NCAAF | 11/06 17:00 | 1 | Depauw Tigers v Oberlin Yeomen | W | 66-13 | |
| NCAAF | 10/30 17:00 | 1 | Depauw Tigers v Denison Big Red | W | 27-10 | |
| NCAAF | 10/23 17:00 | 1 |
Allegheny Gators
v
Depauw Tigers
|
W | 14-38 | |
| NCAAF | 10/16 17:00 | 1 | Depauw Tigers v Ohio Wesleyan Battling Bishops | W | 24-7 | |
| NCAAF | 10/09 18:00 | 1 | Wittenberg Tigers v Depauw Tigers | W | 14-17 |